Letrozole and Breast Cancer: Life After Chemo


In the past, women who had undergone breast cancer have faced infertility due to the chemo, radiation and medicines used to kill abnormal cells. Now, thanks to Letrozole, there is life after cancer – literally.

What is Letrozole?

Letrozole is sold under the trade name Femara. It is part of a group of medications called aromatase inhibitors. (Aromatase is an enzyme that is responsible for the production of estrogen in the body.) Letrozole works by inhibiting aromatase, thereby suppressing estrogen production. The result is that the pituitary gland produces more of the hormones needed to stimulate the ovaries. These hormones, FSH and LH, can cause the development of ovulation in women who are anovulatory (ovaries that don’t ovulate over 3 months) or increase the number of eggs developing in the ovaries of women who ovulate regularly.

Because of Letrozole, breast cancer patients can achieve pregnancy rates comparable to those for women in the general population undergoing in vitro fertilization (IVF),

Double Power: Letrozole Combined with Follice-Stimulating Hormone

Teamwork to the rescue again! Studies show that when Letrozole is combined with follicle-stimulating hormones, an even higher rate of pregnancy can ensue.

This combination protocol seems to be promising because it protects breast cancer patients from traditional ovarian stimulation, which can result in estrogen levels 10 to 20 times higher than physiologic concentrations and raises concern about accelerated tumor growth in patients with estrogen-sensitive tumors.

As reported to Medpage Today, Pamela N. Munster, MD, a breast oncologist at the Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, “The implantation, pregnancy, and live birth rate reported for the returning patients is truly encouraging, particularly given a mean age of 41.5 years and the 5-year delay.”

If women who’ve been through breast cancer can look forward to having children, you can, too.

Contact GlobalIVF

No matter where you live, GlobalIVF.com is your main resource in exploring all of your international options including comparing costs, asking questions and getting answers. Global IVF.com is here to help you get started, keep going and have a baby! Feel free to contact us! 


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