Faulty genes One of the Main Reasons for Male Infertility


Genetic inconsistency have been described as one of main reasons for male infertility in India.

A report documented by the Department of Atomic Energy (DAE) and Council for Scientific and Industrial Research (CSIR), with assistance from the Banaras Hindu University (BHU), has called for genetic screening of infertility cases in males before referring childless couples IVF.

Infertility is a multi-factorial disorder effecting 8% of couples worldwide and among them half can be traced to males.

“Different factors contribute to male infertility including various gene defects and chromosomal abnormalities,” said Dr Kiran Singh, assistant professor, department of molecular and human genetics, BHU.

“The incidence of chromosomal aberrations in population is close to 0.6% whereas infertile men have an 8-10-fold higher frequency of chromosomal anomalies than fertile men,” she said strongly recommending genetic karyotyping (chromosome analyses).

Doctors insist that genetics plays a vital role in maintenance of normal sperm production and in about 30% of infertile males; chromosomal abnormalities and gene mutations have been associated with infertility.

Doctors at BHU tested 412 patients and studies show that 5.56% had chromosomal anomalies.

All patients with chromosomal anomalies were Azoospermic -when mature sperm are not found in the semen because of sperm production failure at various stages- and they were presented one or the other feature of Klinefelter syndrome, a male genetic disorder.

“We have submitted the report to the CSIR and recommended nurturing more geneticists.

“With infertility cases recording a speedy increase in north India, there are people who are making money out of the people’s problems.

“Genetic aspect is generally not looked into with regard to infertile couples,” Dr Singh said.

Women are often held responsible for not conceiving and men are hesitant about being tested.

“Even if they undergo tests, doctors seldom think of genetic factors behind infertility,” she said.

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