GCRM (Glasgow Centre for Reproductive Medicine )was the 1st clinic in the world to conceive a baby with the Early Embryo Viability Assessment Eeva™ test. Eva, named like the test, was born on 11th June 2013 to Susan and David Dempster.
1. Why do you choose to offer the Eeva test at your clinic? Do you offer it because you want to improve your success rates?
We offer the Eeva test because it is the only validated time-lapse imaging system on the market.
We were among the first clinics to offer the Eeva test and are very proud to be the first clinic in the world to have conceived a baby with Eeva. This demonstrated how successful this new IVF technology can be in enabling couples to have a higher chance of conceiving a baby with IVF. GCRM has always strived to be one of the leading IVF Centres in Europe, offering couples the latest innovations and best possible outcomes. The Eeva test is the practical end point of good quality research and is the start of a new chapter in the evolution of IVF.
Offering the test is more than just “improving success rates”. It’s about making the choice of the best embryo more scientific and objective. Having the test should improve success rates but it can also show couples with multiple failed attempts why they aren’t conceiving.
2. What is the Eeva™ Test ?
Eeva is an innovative, automated test that provides objective, quantitative data about early embryo development. At the heart of Eeva is intelligent software that analyzes the time-lapse images for critical and subtle differences in early embryo cell divisions to determine an embryo’s potential for further development. Eeva assists my embryologists in selecting the best embryos for IVF transfer to optimize the chances for a successful pregnancy.
Eeva consists of a special microscope that fits inside a standard incubator and takes video images of your embryos, which are analyzed by proprietary, intelligent software. Your embryos go in to the incubator and never leave the incubator. A camera takes an image every 5 minutes and a computer determines when the cells divide.
3. What are the advantages of the Eeva test?
In standard IVF embryos are removed from the incubator once a day to be checked under the microscope. The Eeva Test is a non-invasive test, which means the embryos go in to the incubator and never leave the incubator. Data suggests that the less disturbance embryos experience, the better.
Eeva is designed to predict blastocyst development by the morning of day 3 of embryo development (cleavage stage). This means that embryos can be transferred on day 3.
This is important because there is growing evidence that adverse epigenetic phenomena and monozygotic twinning are more likely with blastocyst transfer.
Further, Eeva has been shown to increase the consistency of embryo assessment across embryologists.
4. How does it compare to other embryo screening options? Does GCRM have data to back up higher success rates using Eeva?
Eeva is the only clinically validated time-lapse imaging system that uses intelligent software to analyze and determine an embryo’s viability.
The Eeva Test was validated in a prospective, multicenter, 160-patient clinical trial with 1,816 embryos. Embryologists using the Eeva Test were significantly able to improve their ability to identify non-viable embryos relative to traditional methods alone. Additionally, the Eeva Test was able to increase the consistency of embryo assessment across embryologists. Results of this study were presented in July 2012 at the European Society of Human Reproduction and Embryology (ESHRE) annual meeting and published by Conaghan et al in Fertility and Sterility, May 2013.
5. How long has it been available at GCRM?
Since Oct 2012.
6. Do I have to work with a clinic that offers it?
Yes. Check here for clinic locations.
7. What does it cost?
£850 [at GCRM] approx: US$1275 or 1000 Euros
in addition to IVF costs.
8. Who would you recommend this test to?
Women with repeat miscarriages? Women over 40? Poor responders?
We think that all patients undergoing IVF can benefit from Eeva as it gives information that can help the couple make better informed choices.
For patients likely to have multiple embryos for transfer, Eeva provides actionable information to improve selection of the most viable embryos for transfer.
9. Are there any disadvantages to it?
10. Is there any video involved? Do the IPs get to see all the results?
Yes, and the patients get to keep a copy of the video.
11. Does this test increase my chances of IVF success?
Yes. We are now seeing an uplift in pregnancy rates for women using EEVA compared with matched women who didn’t use it. For the time period that we have been using EEVA, all couples where the woman is under 42 years old with 2 or more embryos, the clinical pregnancy rate (i.e. a fetal heartbeat on ultrasound scan) is 37% (no EEVA, N = 286) and 44% (with EEVA, N = 86).
12. Is the Eeva test only available in England at this time? When do they expect it to go to other countries?
The Eeva test is currently available in the UK, Ireland and Spain.
Article by: Dr Marco Gaudoin
GCRM is a member of the ‘Academic Reproductive Partnership’ (ARP). ARP was formed by the merger of a number of the UK’s leading fertility clinics. The partnership is currently the largest single provider of NHS and private IVF services in the UK.
GCRM provides patients with access to the very latest fertility treatment techniques. Patients also benefit from the sharing of best practice and scientific resources by teams across the UK who are at the pinnacle of the assisted reproduction sector.
Please visit GCRM for more information.